ABSTRACT
Background: Complication of diabetes mellitus (DM) includes coagulation impairment. Hypercoagulable state in patient with DM may accelerate thromboembolic risk for cardiovascular disease (CVD). Objective: To assess Prothrombin Time and Activated Partial Thromboplastin Time in type 2 diabetes mellitus for observing their coagubility status. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2013 to June 2014. One hundred male patients with type 2 diabetes mellitus aged 40-60 years and one hundred age, BMI matched healthy subjects were included as control in this study. Patients were selected from BIRDEM, Dhaka. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) were estimated by auto analyzer. For statistical analysis unpaired student’t test was used. Results: In this study PT and APTT were significantly (P<0.001) lower in diabetes mellitus than those of control group. Conclusion: From this study, it may be concluded that diabetic patients are prone to develop coagulation impairment.
ABSTRACT
Background: Heart rate variability has been considered as an indicator of autonomic nerve function status. Few works have been done to assess the heart rate variability in normal healthy subjects in different countries. Objectives: To assess the cardiac autonomic nerve function status in healthy Bangladeshi population of different age groups by analyzing time domain measures of Heart Rate Variability. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from the period of July 2012 to June 2013. For this purpose, a total number of 180 healthy subjects were selected with the age ranging from 15-60 years of both sexes. All the study subjects were divided into 3 different groups according to age (Control 15-30 years; middle age 31-45 years; older age 46-60 years). Each group included 60 subjects of which 30 were male and 30 were female. The subjects were selected from different areas of Dhaka city by personal contacts. HRV parameters were recorded by a 4 active channels, RMS Polyrite-D-2 machine For statistical analysis, one way ANOVA, unpaired Student’s ‘t’-test and Pearson’s correlation coefficient test were performed. as applicable. Results: Systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly (p<0.001) higher in older group in comparison to control & middle age group. Again RR interval and RMSSD (p<0.001), were significantly lower in older age group (p<0.05) compared to control & also to middle age group. But HR was found significantly higher (p<0.05)in both middle and older subjects than control and also in older (p<0.05) compared to middle age. Correlation analysis showed moderate negative correlation of mean R-R with age in middle age whereas significant negative correlation for RMSSD both in middle and older age subjects.. Conclusion: In this study, markedly decreased cardiac parasympathetic function were found with aging process.
ABSTRACT
Background: In obesity insulin hypersecretion is a key feature indicating the abnormal pancreatic beta cell function which is the fundamental defect in the development of NIDDM, hypertension and cardiovascular diseases. Objective: To assess the secretory status of insulin in adult obese female. Methods: The present study was a cross sectional analytical study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. 50 obese female subjects of 20-40 years were included from Out-patient Department (Obesity clinic) of BIRDEM Hospital, Dhaka and by personal contact from different areas of Dhaka city. 50 age matched, healthy non-obese female subjects selected as controls . Fasting serum insulin level was measured by ELISA and fasting glucose level was measured by Glucose oxidase method. The insulin secretory status was calculated by HOMA-%B using HOMA software. For statistical analysis unpaired Student’s ‘t’ test and Pearson’s correlation coefficient (r) test were performed as applicable . Result: Mean fasting serum insulin and HOMA%B (P<0.001) were higher in the obese than that non obese. Fasting serum insulin level and HOMA%B showed significantly positive correlation with WHR. Conclusion: This study concludes that obese individual develops a state of insulin hypersecretion and hyperinsulinemia.
ABSTRACT
Background: An association between essential hypertension and defective insulin secretion has been identified. Objective: To estimate fasting serum insulin level in adult male with essential hypertension to observe its relationship to hypertension. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. A total number of one hundred fifty male subjects were selected with age ranging from 25 to 45 years. Seventy five male essential hypertensive were enrolled from Out- patient Department of Medicine, Dhaka Medical College Hospital, Dhaka. Age matched seventy five apparently healthy males were studied as control. Fasting serum insulin level was measured by ELISA method and fasting blood glucose by glucose oxidase method. For statistical analyses, unpaired Student’s ‘t’ and Pearson’s correlation coefficient (r) tests were performed. Results: Fasting serum insulin level was significantly (P<0.001) higher in essential hypertensive male patients than normotensive subjects. Fasting serum insulin level shows significant positive correlation with systolic blood pressure in hypertensive patients. Conclusion: This study reveals that essential hypertension has positive and significant relationship with fasting serum insulin level.